Emerging tools for bioluminescence imaging

نویسندگان

چکیده

Bioluminescence (BL) relies on the enzymatic reaction between luciferase, a substrate conventionally named luciferin, and various cofactors. BL imaging has become widely used technique to interrogate gene expression cell fate, both in small large animal models of research. Recent developments include generation improved luciferase–luciferin systems for deeper more sensitive as well new caged luciferins report activity other intracellular functions. Here, we critically evaluate emerging tools aiming provide reader with an updated compendium latest (2018–2020) their notable applications.

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ژورنال

عنوان ژورنال: Current Opinion in Chemical Biology

سال: 2021

ISSN: ['1367-5931', '1879-0402']

DOI: https://doi.org/10.1016/j.cbpa.2021.02.005